Maternal serum endothelial cell-specific molecule-1 level and its correlation with severity of early-onset preeclampsia

Ovayolu A., Karaman E., TURGUT A., Guler S., BOSTANCIERİ N.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, vol.41, no.6, pp.893-898, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.1080/01443615.2020.1819215
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.893-898
  • Keywords: Biomarker, cardiovascular diseases, endocan, endothelial cell activation, endothelial dysfunction, predict
  • Van Yüzüncü Yıl University Affiliated: Yes


Preeclampsia (PE), the primary pathology of which is endothelial cell (EC) dysfunction, has long-lasting effects such as cardiovascular disease. Therefore, it was decided to investigate the maternal serum concentrations of EC-specific molecule-1 in patients with early-onset preeclampsia (E-PE). This study was conducted on 33 pregnant women with E-PE and 35 healthy pregnant women matched for gestational age. EC-specific molecule-1 level was measured using a commercially available enzyme-linked immunosorbent assay kit. The mean EC-specific molecule-1 concentrations were not significantly different between the groups (651.7 +/- 632.2 pg/mL vs. 425.9 +/- 263.0 pg/mL, p=.056). Among women with E-PE, the median EC-specific molecule-1 concentration did not differ significantly by disease severity (p=.115). EC-specific molecule-1 is not involved in the pathogenesis of E-PE. However, some studies in the literature report that EC-specific molecule-1 concentrations increased during the diagnosis of PE. Therefore, well-designed studies with a large sample are needed in cases of E-PE. Impact Statement