Publications & Works

Publication Network
Articles 41
All (41)
SCI-E, SSCI, AHCI (29)
SCI-E, SSCI, AHCI, ESCI (29)
Scopus (37)
TRDizin (10)
Other Publications (2)

1. New targets and biomarkers for doxorubicin-induced cardiotoxicity in humans: implications drawn from toxicogenomic data and molecular modelling.

Karakuş F., Ece A., Kuzu B.
Journal of biomolecular structure & dynamics , vol.44, no.2, pp.1038-1050, 2026 (SCI-Expanded, Scopus) identifier identifier

2. Exploring the role of quercetin on doxorubicin and lapatinib-mediated cellular and mitochondrial responses using in vitro and in silico studies

Ergüç A., Albayrak G., Muhammed M. T., Karakuş F., Arzuk E., İnce Ergüç E.
JOURNAL OF CHEMOTHERAPY , vol.38, no.1, pp.32-46, 2026 (SCI-Expanded, Scopus)

3. Design, Synthesis, and Evaluation of Benzoxazole-linked Pyrazole Hybrids as VEGFR-2-targeted Antiproliferative Agents

Deniz E., ÇÖVEN F. O., Ergüç A., Karakuş F., Kuzu B.
Cell Biochemistry and Biophysics , vol.83, no.4, pp.4961-4975, 2025 (SCI-Expanded, Scopus) identifier identifier

4. Synthesis, Antiproliferative Activity, and Pre-Admet Studies of P-Aminophenyl Substituted Benzoxazole Derivatives Designed Based on Phortress

Ergüç A., Karakuş F., ARZUK E., Kuzu B.
Pharmaceutical Chemistry Journal , vol.59, no.5, pp.555-562, 2025 (SCI-Expanded, Scopus) identifier

5. Design, Synthesis, and Evaluation of Pyrrolopyrazine-Substituted Benzoxazole/Benzothiazole Derivatives Targeting Aurora Kinase A in MCF-7 Cells

Kuzu B., Köstekci S., Karakuş F., Tülüce Y.
ChemistrySelect , vol.10, no.22, 2025 (SCI-Expanded, Scopus) identifier

6. In Silico Network Toxicology, Molecular Docking, and Multi-Level Bioinformatics Reveal Methyl Eugenol-Induced Hepatocellular Carcinoma Mechanisms in Humans

Karakuş F., Tanrıverdi Z., Kuzu B.
Cancer Medicine , vol.14, no.10, 2025 (SCI-Expanded, Scopus) identifier identifier

7. Mechanisms of developmental neurotoxicity of Dechlorane Plus, a recently identified persistent organic pollutant: An in silico study

Karakuş F., Kuzu B.
NEUROTOXICOLOGY , vol.108, pp.318-327, 2025 (SCI-Expanded, Scopus) identifier identifier

8. An in silico analysis of dicofol-induced neurotoxicity mechanisms in humans

Karakuş F., Kuzu B.
Neurotoxicology and Teratology , vol.109, 2025 (SCI-Expanded, Scopus) identifier identifier

9. Screening and toxicity evaluation of natural compounds as adenosine 2a and 2b receptor ligands: insights from molecular docking, dynamics, and ADMET analysis.

Karakuş F., ALAGÖZ M. A., Kuzu B.
Drug and chemical toxicology , vol.48, no.3, pp.606-615, 2025 (SCI-Expanded, Scopus) identifier identifier

10. Mechanistic Analysis of Decabromodiphenyl Ether-Induced Neurotoxicity in Humans Using Network Toxicology and Molecular Docking

Karakuş F., Kuzu B.
Neurotoxicity Research , vol.43, no.2, 2025 (SCI-Expanded, Scopus) Creative Commons License identifier identifier

11. Investigation the immunotherapeutic potential of miR-4477a targeting PD-1/PD-L1 in breast cancer cell line using a CD8(+) co-culture model.

Tülüce Y., Köstekci S., Karakuş F., Keleş A. Y., Tunçyürekli M.
Molecular biology reports , vol.52, no.1, pp.326, 2025 (SCI-Expanded, Scopus) Sustainable Development identifier identifier

12. Exploring Natural Compounds Targeting PD-L1 and STAT3: Toxicogenomic Analysis, Virtual Screening, Molecular Docking, ADMET Evaluation, and Biological Activity Prediction

Karakuş F., Kuzu B., Köstekci S., Tülüce Y.
CURRENT COMPUTER-AIDED DRUG DESIGN , vol.21, no.3, pp.348-361, 2025 (SCI-Expanded, Scopus)

13. Mitochondrial toxicity of selected natural compounds: in vitro assessment and in silico molecular docking and dynamics simulation.

Ergüç A., Albayrak G., Muhammed M. T., Karakuş F., Arzuk E.
Drug and chemical toxicology , vol.48, no.1, pp.199-209, 2025 (SCI-Expanded, Scopus) identifier identifier

14. Investigation of potential anti-metastatic effect of metformin and caffeic acid combination therapy in breast cancer cell line in in-vitro culture model.

Yavuz H., Tülüce Y., Karakuş F., Köstekci S., Tunçyürekli M., Keleş A. Y.
MEDICAL ONCOLOGY , vol.42, no.2, pp.38, 2025 (SCI-Expanded, Scopus) Sustainable Development identifier identifier

15. DESIGN, SYNTHESIS, AND EVALUATION OF ANTIBACTERIAL POTENTIAL OF HYDRAZONE-TETHERED PYRAZOLE-THIAZOLE DERIVATIVES

Kuzu B., Yiğit A., Karakuş F.
Journal of Faculty of Pharmacy of Ankara University , vol.49, no.1, pp.42-52, 2025 (Scopus, TRDizin) identifier identifier

16. Synthesis of thiazole-integrated pyrrolotriazinones: evaluations of cytotoxicity and effects on PI3K levels in cancer cells

Kuzu E., Arzuk E., Karakuş F., Kuzu B., Genç H.
Turkish Journal of Chemistry , vol.49, no.2, pp.215-227, 2025 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

17. Network toxicology reveals mechanisms of Endosulfan-induced lung injury

Karakuş F., Kuzu B.
Inhalation Toxicology , vol.37, no.7-8, pp.357-368, 2025 (SCI-Expanded, Scopus) identifier identifier

18. Predicting the molecular mechanisms of cardiovascular toxicity induced by per- and polyfluoroalkyl substances: an In Silico network toxicology perspective

Karakuş F., Kuzu B.
Toxicology Research , vol.13, no.6, 2024 (SCI-Expanded, Scopus) identifier identifier

19. Network Toxicology for The Cardiovascular Toxicity analysis of Tyrosine Kinase Inhibitors

Karakuş F.
Journal of Faculty of Pharmacy of Ankara University , vol.48, no.3, pp.929-939, 2024 (Scopus, TRDizin)

20. Mitochondrial Impact of Organophosphate Pesticide-Induced Cardiotoxicity: An In Silico and In Vitro Study.

Karakuş F., Arzuk E., Ergüç A.
International journal of toxicology , vol.43, no.5, pp.464-471, 2024 (SCI-Expanded, Scopus) identifier identifier

21. A Network Toxicology Analysis of the Molecular Pathways and Novel Targets in TCDD-Induced Cardiovascular Toxicity TCDD ile Indöklenen Kardiyovasköler Toksisitede Moleköler Yolaklarin ve Yeni Hedeflerin Aǧ Toksikolojisi Analizi

Karakuş F.
Fabad Journal of Pharmaceutical Sciences , vol.49, no.2, pp.359-370, 2024 (Scopus, TRDizin) identifier

22. Effect of n-Hexane Extract from Tanacetum argenteum (Lam.) Willd. subsp. argenteum on the Secretion of Proinflammatory Cytokines in THP-1 Cell Line

Arzuk E., Karakuş F., Albayrak G., Ergüç A., Tan İ., Atış E.
FABAD JOURNAL OF PHARMACEUTICAL SCIENCES , vol.49, no.1, pp.233-244, 2024 (Scopus, TRDizin) identifier identifier

23. Novel Pyrazole Derivatives Bearing Carbonitrile and Substituted Thiazole Moiety for Selective COX-2 Inhibition

Arzuk E., Karakuş F., Ergüç A., Kuzu B.
ChemistrySelect , vol.9, no.1, 2024 (SCI-Expanded, Scopus) identifier

24. In silico and in vitro evaluation of oxypeucedanin-induced anticancer activity: Mitotoxicity?

Ergüç A., Okur H., Karakuş F., Albayrak G., Arzuk E., Baykan Öztürk Ş.
Journal of Health Sciences of Adıyaman University , vol.9, no.3, pp.153-161, 2023 (TRDizin)

25. In Silico and In Vitro Anticancer Effects of Caffeic Acid Phenethyl Ester on Pancreatic Adenocarcinoma Cells

Tanrıverdi Z., Kuzu B., Eyol E., Karakuş F.
FABAD JOURNAL OF PHARMACEUTICAL SCIENCES , vol.48, no.3, pp.513-522, 2023 (Scopus, TRDizin) identifier identifier

26. Potential inhibitors of extra-synaptic NMDAR/TRPM4 interaction: Screening, molecular docking, and structure-activity analysis

Deniz E., Karakuş F., Kuzu B.
Computational Toxicology , vol.27, 2023 (Scopus) identifier

27. Design, synthesis, and antiproliferative activities of novel thiazolyl-pyrazole hybrid derivatives

Kuzu B., Ergüç A., Karakuş F., Arzuk E.
Medicinal Chemistry Research , vol.32, no.8, pp.1690-1700, 2023 (SCI-Expanded, Scopus) identifier

28. Isoimperatorin-mediated anticancer activity: Role of Mitochondrial Dysfunction in HepG2 Cells

Ergüç A., Arzuk E., Albayrak G., Karakuş F., Okur H., Baykan Öztürk Ş.
ANKARA UNIVERSITESI ECZACILIK FAKULTESI DERGISI , vol.47, no.3, pp.13-22, 2023 (Scopus, TRDizin)

29. Role of Oxidative Stress and Reactive Metabolites in Cytotoxicity & Mitotoxicity of Clozapine, Diclofenac and Nifedipine in CHO-K1 Cells In Vitro.

Ergüç A., Karakuş F., Arzuk E., Mutlu N., Orhan H.
Endocrine, metabolic & immune disorders drug targets , vol.23, pp.1725-1739, 2023 (SCI-Expanded, Scopus) identifier identifier

30. Natural Compounds Targeting VEGFRs in Kidney Cancer: An In silico Prediction

Kuzu B., Karakuş F.
Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi , vol.12, no.3, pp.1711-1722, 2022 (TRDizin)

31. Possible Cardioprotective Mechanism of Action of Dexrazoxane, and Probable Human Topoisomerase IIβ Inhibitors: An In Silico Analysis

Karakuş F., Kuzu B.
ANKARA UNIVERSITESI ECZACILIK FAKULTESI DERGISI , vol.46, no.2, pp.474-486, 2022 (Scopus, TRDizin) identifier identifier

32. Mitochondrial Biotransformation of Drugs and other Xenobiotics.

Orhan H., Karakuş F., Ergüç A.
Current drug metabolism , vol.22, no.8, pp.657-669, 2021 (SCI-Expanded, Scopus) identifier identifier identifier

33. Bioactivation of clozapine by mitochondria of the murine heart: Possible cause of cardiotoxicity

ARZUK E., Karakuş F., ORHAN H.
TOXICOLOGY , vol.447, 2021 (SCI-Expanded, Scopus) identifier identifier identifier

34. Combination of 2 Bioactive Compounds for Treatment of Breast Cancer: Triterpenoid Cucurbitacin I and Phenolic CAPE

Karakuş F., Yilmaz K., Eyol E., ÜNÜVAR S.
NATURAL PRODUCT COMMUNICATIONS , vol.14, no.6, 2019 (SCI-Expanded, Scopus) Creative Commons License Sustainable Development identifier identifier

35. Antineoplastic activity of cucurbitacin I in CC531 rat colorectal cancer cells

Eyol E., Karakuş F., Yılmaz K., Tosun E., Kovacheva M., Zepp M., et al.
JOURNAL CLINICAL ONCOLOGY AND RESEARCH , vol.2, no.1, pp.1-8, 2019 (Peer-Reviewed Journal) Sustainable Development

36. Inhibition of cell proliferation, migration and colony formation of LS174T Cells by carbonic anhydrase inhibitor

Karakuş F., Eyol E., Yilmaz K., ÜNÜVAR S.
AFRICAN HEALTH SCIENCES , vol.18, no.4, pp.1303-1310, 2018 (SCI-Expanded, Scopus) Creative Commons License Sustainable Development identifier identifier identifier

37. Cytotoxic Effects of Cucurbitacin I and Ecballium elaterium on Breast Cancer Cells

Yilmaz K., Karakuş F., Eyol E., TOSUN E., YILMAZ İ., ÜNÜVAR S.
NATURAL PRODUCT COMMUNICATIONS , vol.13, no.11, pp.1445-1448, 2018 (SCI-Expanded, Scopus) Sustainable Development identifier

38. In vitro effect of carbonic anhydrase inhibitor acetazolamide on cell viability, migration and colony formation of colorectal cancer cells

Karakuş F., Eyol E., Yilmaz K., ÜNÜVAR S.
BIOLOGIA , vol.73, no.6, pp.621-628, 2018 (SCI-Expanded, Scopus) Sustainable Development identifier identifier

39. The relationship between neopterin and hepatitis B surface antigen positivity

ÜNÜVAR S., Aslanhan H., Tanriverdi Z., Karakuş F.
PTERIDINES , vol.29, no.1, pp.1-5, 2018 (SCI-Expanded, Scopus) Sustainable Development identifier identifier

40. Synergistic Anti-proliferative Effects of Cucurbitacin I and Irinotecan on Human Colorectal Cancer Cell Lines

Eyol E., Tanrıverdi Z., Karakuş F., Yılmaz K., Ünüvar S.
Journal of Clinical & Experimental Pharmacology , vol.6, no.5, pp.1-6, 2016 (Peer-Reviewed Journal) Sustainable Development

41. Effect of the Achillea wilhelmsii extract intake upon blood lipid profile, haematologic and immunologic parameters in the rat

Suzergoz F., ÇINAR S., Oktay R., Karakuş F., GÜROL A. O.
FOOD AND AGRICULTURAL IMMUNOLOGY , vol.26, no.1, pp.46-59, 2015 (SCI-Expanded, Scopus) identifier identifier
Papers Presented at Peer-Reviewed Scientific Conferences 19

1. METOKSİKLOR’UN POTANSİYEL NÖROTOKSİSİTE MEKANİZMALARININ İN SİLİKO ARAŞTIRILMASI

Karakuş F.
Van Yüzüncü Yıl Üniversitesi 4. Uluslararası Sağlık Bilimleri Kongresi, Van, Turkey, 15 - 16 December 2025, pp.99, (Summary Text)

2. ELUCIDATION OF THE MECHANISM OF CARFILZOMIB-INDUCED CARDIOTOXICITY IN HUMANS THROUGH NETWORK TOXICOLOGY AND BIOINFORMATICS

Subay Z. G., Karakuş F.
Van Yüzüncü Yıl University 3rd International Health Sciences Congress, Van, Turkey, 12 - 13 December 2024, pp.112, (Summary Text) Creative Commons License

3. Investigation of the potential anti-metastatic effect of combined treatment of metformin (MET) and caffeic acid (CA) in breast cancer cell line in-in vitro culture model

Yavuz H., Tülüce Y., Karakuş F., Köstekci S., Tunçyürekli M., Keleş A. Y.
I. International Conference on Chemistry and Biotechnology (EUCHEMBIOJ 2024), İstanbul, Turkey, 09 December 2024, pp.14, (Summary Text) Sustainable Development

4. DESIGN AND IN SILICO ANALYSIS OF GLP1R AGONISTS

Deniz E., Karakuş F., Kuzu B.
Van Yüzüncü Yıl Üniversitesi 2. Uluslararası Sağlık Bilimleri Kongresi , Van, Turkey, 18 - 19 December 2023, pp.39, (Summary Text) Creative Commons License

5. In Silico Drug Repurposing As Inhibitors Against Gsk-3β

Deniz E., Karakuş F., Kuzu B.
International Multidisciplinary Symposium on Drug Research and Development - DRD 2023, İzmir, Turkey, 4 - 06 May 2023, pp.112, (Summary Text) Creative Commons License

6. Role of Mitochondria in Doxorubicin-Induced Cardiotoxicity

Karakuş F.
1st International Health Sciences Research Days Congress, İstanbul, Turkey, 14 - 16 September 2022, pp.19, (Summary Text)

7. In Silico Toxicity Profiles of Some Natural Protective Compounds Against Anthracycline-Induced Cardiotoxicity

Karakuş F.
UNION OF THRACE UNIVERSITIES V. INTERNATIONAL HEALTH SCIENCES CONGRESS 2022, Balıkesir, Turkey, 1 - 02 December 2022, pp.67, (Summary Text)

8. Paracetamol-associated adverse reactions in kidney: Different mechanistic pathways compared to liver

Orhan H., Karakuş F., Atmaca K., Aladağ B.
56th Congress of the European Societies of Toxicology, 27 September - 01 October 2021, vol.350, pp.55-56, (Summary Text)

9. Cysteine conjugate of paracetamol serves as substrate for kidney cysteine S-conjugates β-lyase: implications for drug-induced acute kidney injury

Karakuş F., Atmaca K., Aladağ B., Orhan H.
56th Congress of the European Societies of Toxicology , 27 September - 01 October 2021, pp.164, (Summary Text)

10. Comparative Cysteine S-Conjugate β-Lyase Activities of Different Organs Towards Paracetamol in Mice

Karakuş F., Atmaca K., Aladağ B., Orhan H.
13th International Symposium on Pharmaceutical Sciences, Ankara, Turkey, 22 - 25 June 2021, (Unpublished)

11. Involvement of Reactive Metabolites in Cytotoxic Effects of Various Frequently Used Drugs In Vitro

Ergüç A., Mutlu N., Arzuk E., Karakuş F., Orhan H.
12th International Symposium on Pharmaceutical Sciences, Ankara, Turkey, 26 - 29 June 2018, (Unpublished)

12. Biotransformation of clozapine by microsomal and mitochondrial fractions of mouse liver and heart: Organ-specific bioactivation as a possible cause of cardiotoxicity

ARZUK E., Karakuş F., ORHAN H.
52nd Congress of the European-Societies-of-Toxicology (EUROTOX), Sevilla, Spain, 4 - 07 September 2016, vol.258, (Summary Text) identifier

13. Antiproliferative potential of Pistacia terebinthus L. on Breast Cancer Cell Lines

İçen M. S., Karakuş F., Tosun E., Yılmaz K.
1st International Gazi Pharma Symposium Series GPSS-2015 , Antalya, Turkey, 12 November 2015 - 15 November 2021, pp.172, (Summary Text) Sustainable Development

14. Cytotoxic Effect of Cape on Breast Cancer MCF-7 and MDA-MB-231 Cells

Karakuş F., Tosun E., Yılmaz K., Eyol E.
1st International Gazi Pharma Symposium Series GPSS-2015 , Antalya, Turkey, 12 - 15 November 2015, pp.126, (Summary Text) Sustainable Development

15. Contribution of reactive metabolites to mitochondrial damage in CHO-K1 cells exposed to various drugs

Mutlu N., Ergüç A., Karakuş F., Orhan H.
Turkheltox 2015 Meeting , İzmir, Turkey, 21 - 24 October 2015, pp.1, (Summary Text)

16. Effect of Acetazolamide on Colon Cancer Cells

Karakuş F., Tosun E., Yılmaz K., Eyol E.
International Multidisciplinary Symposium on Drug Research and Development , Eskişehir, Turkey, 15 - 17 October 2015, pp.121, (Summary Text) Sustainable Development

17. Growth inhibitory effects of Cucurbitacin I on breast cancer cells

Yılmaz K., Karakuş F., Tosun E., Eyol E.
1st International Conference on Natural Products for Cancer Prevention and Therapy, İstanbul, Turkey, 31 August - 02 September 2015, vol.26, pp.23, (Summary Text) Sustainable Development

18. Ecballium elaterium L. Ekstraktlarının Göğüs Kanser Hücreleri Üzerine Etkisi

Yılmaz K., Tosun E., Karakuş F., Eyol E.
3. İlaç Kimyası: İlaç Etkin Maddesi Tasarımı, Sentezi, Üretimi ve Standardizasyonu Kongresi , Antalya, Turkey, 20 - 22 March 2015, pp.148, (Summary Text) Sustainable Development

19. Achillea wilhelmsii Ektresinin Yüksek Yağlı Diyetle Obezite Geliştirilmiş Ratlarda Kan Lipit Profili Üzerine Etkileri

Süzergöz F., Oktay R., Aksu U., Çınar S., Karakuş F., Gürol A. O.
21. Ulusal Biyoloji Kongresi , İzmir, Turkey, 3 - 07 September 2012, pp.365, (Summary Text) Sustainable Development
Books 9

1. Tetrodotoxin

Karakuş F.
in: FOOD SAFETY, Yağmur Emre Arıcan,Emir Hasan Osmanoğlu, Editor, Nobel Yayınevi, İstanbul, pp.125-133, 2024

2. PHARMACOLOGY AND TOXICOLOGY OF CANNABINOIDS

Haspolat Y. K. (Editor), Karakuş F. (Editor), Tanrıverdi Z. (Editor)
Orient Yayınları, Ankara, 2023

3. Kenevir'in Biyopestisit Olarak Kullanışı

Karakuş F., Tanrıverdi Z.
in: Farklı Yaklaşımlarla Endüstriyel Alanında Kenevir, Yusuf Kenan Haspolat,Enver Akın, Editor, Orient Yayınları, Ankara, pp.71-74, 2022

4. Kenevir'in İnsan Sağlığı Üzerine Olumsuz Etkileri

Karakuş F., Tanrıverdi Z.
in: Farklı Yaklaşımlarla Sağlık Alanında Kenevir, Yusuf Kenan Haspolat,Gönül Ölmez Kavak, Editor, Orient Yayınları, Ankara, pp.312-316, 2022

5. PRODUCTION OF CANNABINOIDS IN THE PHARMACEUTICAL INDUSTRY

Kuzu B., Karakuş F., Tanrıverdi Z.
in: CANNABINOIDS IN PHARMACEUTICAL INDUSTRY, Mine Koçyiğit AVCI,Yusuf Kenan HASPOLAT,Yağmur Emre ARICAN, Editor, Orient Yayınları, Ankara, pp.8-19, 2022 Creative Commons License

6. Application and Technology of Hemp Oil

Tanrıverdi Z., Karakuş F., Eyol E.
in: Industrial Hemp Technology, Mine Koçyiğit AVCI,Yusuf Kenan HASPOLAT,Yağmur Emre ARICAN, Editor, Orient Yayınları, Ankara, pp.52-58, 2022 Creative Commons License

7. Toxicology of Herbal Medicines

Orhan H., Arzuk E., Karakuş F., Ergüç A.
in: Toxicology for the Health and Pharmaceutical Sciences, Antonio Peña-Fernández,Mark D. Evans,Marcus S. Cooke, Editor, CRC, New York , Florida, pp.192-222, 2021

8. Türkiye'de Mantar Zehirlenmeleri ve Tedavi Yaklaşımları

Karakuş F.
in: Çocuk Kronik Hastalıklarında Beslenme, Prof. Dr. Yusuf Kenan Haspolat,Prof. Dr. Coşkun Çeltik,Prof. Dr. Kürşat Bora Çarman,Doç. Dr. Ulaş Emre Akbulut,Uzm. Dr. Taşkın Taş, Editor, Orient Yayınları, Ankara, pp.289-296, 2021

9. Gıda Zehirlenmelerinde Toksikolojik Yaklaşım

Tanrıverdi Z., Karakuş F.
in: Çocuk Kronik Hastalıklarında Beslenme , Prof. Dr. Yusuf Can Haspolat,Prof. Dr. Coşkun Çeltik,Prof. Dr. Kürşat Bora Çarman,Doç. Dr. Ulaş Emre Akbulut,Uzm. Dr. Taşkın Taş, Editor, Orient Yayınları, Ankara, pp.281-288, 2021
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132

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146

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217

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