In the current study, lipid peroxidation, antioxidant enzymes, antioxidant vitamins, oxidation products of nitric oxide and some biochemical parameter levels in chicken with infectious bursal disease were investigated. Thirty chicken were used in the study, 7 in a control group of healthy individuals and the other 23 chickens were infected naturally. The level of advanced oxidation protein products (AOPP) was not affected by the treatment. Vitamin C (P<0.01), nitrite (P<0.01), catalase (P<0.001) and superoxide dismutase (P<0.001) levels were significantly decreased. The levels of malondialdehyde and nitrate increased significantly (P<0.001), while the amounts of ALT (P<0.05) and Albumin (P<0.001) decreased. We also found that changes in glucose, AST, triglyceride and total protein levels were not affected. On the other hand, increases in the levels of LDL (P<0.01), cholesterol and HDL (P<0.05) were significant.